PXD042046-2

PXD042046 is an original dataset announced via ProteomeXchange.

Title	Repeated bisphenol A exposure in low concentrations alters the functionality and environment of a human induced pluripotent stem cell-derived cardiomyocyte model
Description	Early embryonic development represents a sensitive time-window during which the foetus might be highly vulnerable to the exposure of environmental contaminants, potentially leading to heart diseases also later in life (Developmental Origins of Health and Disease (DOHaD) concept). Bisphenol A (BPA), a synthetic chemical widely used in plastics manufacturing, has been associated with heart developmental defects, even in low concentrations. This study aims to investigate the effects of environmentally relevant doses of BPA on developing cardiomyocytes using a human induced pluripotent stem cell (hiPSC)-derived model.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:40.977.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bachuki Shashikadze
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-07 06:13:00	ID requested
1	2023-08-15 02:41:49	announced
⏵ 2	2023-11-14 09:04:49	announced	2023-11-14: Updated project metadata.

Lamberto F, Shashikadze B, Elkhateib R, Lombardo SD, Hor, á, nszky A, Balogh A, Kistam, á, s K, Zana M, Menche J, Fr, ö, hlich T, Dinny, é, s A, Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut, 335():122359(2023) [pubmed]

submitter keyword: Bisphenol A (BPA), proteomics,DOHaD, extracellular matrix remodelling, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), new approach methodologies (NAMs)

Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	frohlich@genzentrum.lmu.de
lab head
Bachuki Shashikadze
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	shashikadze@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD042046

PRIDE project URI

• PRIDE
  1. PXD042046
     1. Label: PRIDE project
     2. Name: Repeated bisphenol A exposure in low concentrations alters the functionality and environment of a human induced pluripotent stem cell-derived cardiomyocyte model