PXD042026-1

PXD042026 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Targeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Description	Individuals with Alzheimer Disease with psychotic symptoms (AD+P) experience more rapid cognitive and functional decline, and have reduced indices of synaptic integrity, relative to those without psychosis (AD-P). We hypothesized the postsynaptic density (PSD) proteome is altered in AD+P relative to AD-P, and that this proteomic signature could be used to nominate novel pharmacotherapies. METHODS: Liquid-Chromatography/Mass Spectrometry analysis of PSDs from dorsolateral prefrontal cortex of AD+P, AD-P and cognitively normal elderly subjects. RESULTS: The PSD proteome signature of AD+P was characterized by lower levels of a network of kinases, proteins regulating Rho GTPases, and proteins regulating the actin cytoskeleton. Potential novel therapies identified included the C-C Motif Chemokine Receptor 5 inhibitor, maraviroc. DISCUSSION: AD+P is characterized by broad changes in the PSD proteome in prefrontal cortex. Further testing of potential therapies for their ability to reverse these changes and protect against psychotic-like behaviors in model systems is warranted.
HostingRepository	PRIDE
AnnounceDate	2023-06-19
AnnouncementXML	Submission_2023-06-19_02:45:41.025.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD042026
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MatthewMacDonald
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-05 10:11:35	ID requested
⏵ 1	2023-06-19 02:45:41	announced
2	2023-11-14 09:01:57	announced	2023-11-14: Updated project metadata.

Publication List

Krivinko JM, DeChellis-Marks MR, Zeng L, Fan P, Lopez OL, Ding Y, Wang L, Kofler J, MacDonald ML, Sweet RA, Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease. Commun Biol, 6(1):598(2023) [pubmed]
10.6019/PXD042026;

Krivinko JM, DeChellis-Marks MR, Zeng L, Fan P, Lopez OL, Ding Y, Wang L, Kofler J, MacDonald ML, Sweet RA, Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease. Commun Biol, 6(1):598(2023) [pubmed]

10.6019/PXD042026;

Keyword List

submitter keyword: Alzheimer’s Disease
Psychosis
Post-synaptic Density
Proteomics: Systems Pharmacology

submitter keyword: Alzheimer’s Disease

Psychosis

Post-synaptic Density

Proteomics: Systems Pharmacology

Contact List

MatthewMacDonald
contact affiliation	University at Pittsbrugh Department of Psychiatry
contact email	mlmacdonald@gmail.com
lab head
MatthewMacDonald
contact affiliation	University of Pittsburgh
contact email	mlmacdonald@gmail.com
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD042026

PRIDE project URI

Repository Record List

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