PXD042011-2

PXD042011 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of anterior pituitary of heifer calves offered either a high or moderate plane of nutrition in early life
Description	Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in heifer calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in heifers, with the dynamics of gonadotropin pulsatility within the anterior pituitary gland, in particular, central to final sexual maturity. However, the precise molecular mechanisms regulating the influence of metabolic status on this signalling axis in heifer calves is yet to be fully elucidated. The objective of this study was to determine the effect of an enhanced plane of nutrition during early life, up to 21 weeks of age, on the anterior pituitary gland proteome of heifer calves. Heifer calves were offered either a high or moderate plane of nutrition. Pathway analysis of differentially abundant proteins highlighted an effect on both growth hormone and GnRH signalling pathways, as well as an effect towards reproductive system development and function
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:48:52.725.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tara Carthy
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-05 03:32:06	ID requested
1	2024-07-04 03:11:20	announced
⏵ 2	2024-10-22 06:48:53	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: anterior pituitary, diet,heifer calves

David Kenny
contact affiliation	Teagasc
contact email	david.kenny@teagasc.ie
lab head
Tara Carthy
contact affiliation	Teagasc
contact email	tara.carthy@teagasc.ie
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042011
     1. Label: PRIDE project
     2. Name: Proteomic profiling of anterior pituitary of heifer calves offered either a high or moderate plane of nutrition in early life