PXD041964-2

PXD041964 is an original dataset announced via ProteomeXchange.

Title	Caspase-2 is a condensate-mediated deubiquitinase in protein quality control
Description	When cells encounter proteome stresses, caspase-2 accumulates in a ubiquitin-rich condensate, which functions as a deubiquitinase to cleave the overloaded ubiquitinated proteins.
HostingRepository	iProX
AnnounceDate	2023-09-06
AnnouncementXML	Submission_2025-06-13_00:20:50.706.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingwei Ge
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; 4800 Plus MALDI TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-03 20:55:28	ID requested
1	2024-07-18 20:20:27	announced
⏵ 2	2025-06-13 00:20:51	announced	2025-06-13: Add Publication.

Ge Y, Zhou L, Fu Y, He L, Chen Y, Li D, Xie Y, Yang J, Wu H, Dai H, Peng Z, Zhang Y, Yi S, Wu B, Zhang X, Zhang Y, Ying W, Cui CP, Liu CH, Zhang L, Caspase-2 is a condensate-mediated deubiquitinase in protein quality control. Nat Cell Biol, 26(11):1943-1957(2024) [pubmed]

submitter keyword: caspase-2, protein quality control, deubiquitinase

Lingqiang Zhang
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics; Beijing, 100850, China.
contact email	zhanglq@nic.bmi.ac.cn
lab head
Yingwei Ge
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics; Beijing, 100850, China.
contact email	taciturnity@vip.qq.com
dataset submitter

iProX dataset URI