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PXD041959 is an original dataset announced via ProteomeXchange.

Dataset Summary
DescriptionProteomic and phosphoproteomic analysis of MCF7 cells treated with Palbociclib (CDK4/6 inhibitor), PF3600 (CDK2 inhibitor) or both for 1 hour and 24 hours. 'P_1_1' P refers to phosphoproteomic analysis. Otherwise, global proteomics was performed. Number (1,2,3) refers to the run number. 3 runs were performed. Samples were TMT labelled and in each run there were the following samples: DMSO 1 h, DMSO 24 h, 1uM Palbociclib 25nM PF3600 1 h, 1uM Palbociclib 25nM PF3600 24 h, 1uM Palbociclib 1 h, 1uM Palbociclib 24 h, 25nM PF3600 1 h, 25nM PF3600 24 h. Number (1-24 for P or 1-12 for global) refers to the fraction.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLotte Watts
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListO-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine; L-methionine sulfoxide; unknown modification; S-carboxamidomethyl-L-cysteine
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-03 17:37:41ID requested
12023-05-25 16:27:03announced
Publication List
no publication
Keyword List
submitter keyword: CDK inhibitors, CDK2, CDK4/6, MCF7, Breast Cancer
Contact List
John Lapek
contact affiliationBelharra Therapeutics
contact emailjlapek@belharratx.com
lab head
Lotte Watts
contact affiliationUniversity of Colorado
contact emaillotte.watts@colorado.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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