PXD041871 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells |
Description | HSP90 inhibitors (HSP90i) have not entered routinely in the clinics, primarily due to the associated resistance via heat shock response (HSR) induction and dose limiting toxicity. In this study, we employed genetic KO and knockdown (KD) models of HSP90 isoforms (α and β) for extensive multi-omics-based in vitro and in vivo characterization and identified HSP90α as the primary driver of malignancy of the two isoforms in BCR-ABL1+ leukemia cells. Notably, combinatorial ex vivo drug sensitivity screenings identified CDK7 inhibitors (CDK7i) as drugs synergizing with HSP90α inhibition. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-26 |
AnnouncementXML | Submission_2024-01-26_11:54:44.482.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Thomas Lenz |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-28 02:21:08 | ID requested | |
⏵ 1 | 2024-01-26 11:54:45 | announced | |
2 | 2024-10-22 06:27:48 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41419-023-06337-3; |
Vogt M, Dienstbier N, Schliehe-Diecks J, Scharov K, Tu JW, Gebing P, Hogenkamp J, Bilen BS, Furlan S, Picard D, Remke M, Yasin L, Bickel D, Kalia M, Iacoangeli A, Lenz T, St, ü, hler K, Pandyra AA, Hauer J, Fischer U, Wagener R, Borkhardt A, Bhatia S, Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells. Cell Death Dis, 14(12):799(2023) [pubmed] |
Keyword List
submitter keyword: knockout, K562, HSP90alpha, HSP90, HSP90beta, proteome,LC-MSMS, secretome |
Contact List
Kai Stühler |
contact affiliation | Molecular Proteomics Laboratory, Biological Medical Research Center, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany |
contact email | kai.stuehler@hhu.de |
lab head | |
Thomas Lenz |
contact affiliation | MPL/BMFZ, HHU Düsseldorf |
contact email | thomas.lenz@hhu.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041871
- Label: PRIDE project
- Name: Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells