PXD041862-1

PXD041862 is an original dataset announced via ProteomeXchange.

Title	Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Description	Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recovered the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We performed comprehensive single cell transcriptional and proteomic studies of Appl mutant flies to investigate Appl function in the aging brain.
HostingRepository	PRIDE
AnnounceDate	2023-10-04
AnnouncementXML	Submission_2023-10-04_08:53:08.439.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	VanithaNithianandam
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-27 16:22:35	ID requested
⏵ 1	2023-10-04 08:53:08	announced

Dataset with its publication pending

submitter keyword: proteomics, ubiquitinomics, amyloid precursor protein like, Appl,Drosophila melanogaster

Mel B.Feany
contact affiliation	Mel Feany, M.D., Ph.D. Department of Pathology Harvard Medical School Brigham and Women's Hospital Harvard New Research Building, Room 630 77 Avenue Louis Pasteur Boston, MA 02115
contact email	mel_feany@hms.harvard.edu
lab head
VanithaNithianandam
contact affiliation	Brigham and Women's Hospital, Harvard Medical School
contact email	vnithianandam@bwh.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD041862

PRIDE project URI

• PRIDE
  1. PXD041862
     1. Label: PRIDE project
     2. Name: Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging