PXD041852-1

PXD041852 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes
Description	In human somatic cells, ZC3H11A has been recently characterized as an RNA-export protein that functions through its interaction with TREX complex proteins. In order to identify its interacting partners in embryonic cells, and to investigate if ZC3H11A maintains its association with the TREX complex in mouse embryonic stem cells (mESCs), we have performed co-immunoprecipitations (co-IPs) using anti-ZC3H11A, anti-THOC2 and anti-IgG antibodies followed by mass spectrometry (MS) analyses. Statistical analyses of detected MS intensities from the biological replicates (n=4) have revealed a number of proteins with statistically significant interaction with ZC3H11A and THOC2. Results in xlsx format contain the log-fold change in protein intensities in the ZC3H11A co-IP relative to the IgG co-IP and is presented along with the adjusted P-values.
HostingRepository	MassIVE
AnnounceDate	2023-04-27
AnnouncementXML	Submission_2023-04-27_09:28:12.394.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	M�rten Larsson
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion ETD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-27 08:29:09	ID requested
⏵ 1	2023-04-27 09:28:12	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: ZC3H11A, mouse embryonic stem cells, label-free, RNAseq

submitter keyword: ZC3H11A, mouse embryonic stem cells, label-free, RNAseq

Contact List

Shady Younis
contact affiliation	Uppsala University
contact email	syounis@stanford.edu
lab head
M�rten Larsson
contact affiliation	Uppsala University
contact email	Marten.Larsson@imbim.uu.se
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000091811/