PXD041739-1

PXD041739 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Label free quantitative proteomics analysis based on LC-MS in Caki-1 to reveal the pathways associated with ERRα in ccRCC
Description	To investigate the regulatory role of orphan nuclear receptor ERRα in the progression of ccRCC, we conducted the stable knockdown of ERRα in Caki-1 with shRNA lentivirus. The total protein samples of Caki-1 with shCtrl and shERRα were collected and subjected to label free quantitative proteomics analysis based on LC-MS, the differentially expressed proteins were selected based on the p value and fold-changes between two groups. Then, bioinformatics analysis was performed to reveal the pathways and key factors related to ERRα in ccRCC
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:29:12.794.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chun Feng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-22 19:58:49	ID requested
⏵ 1	2025-05-06 09:29:13	announced

Publication List

10.1038/s41419-025-07345-1;
Feng C, Kong D, Tong B, Liang Y, Xu F, Yang Y, Wu Y, Chi X, Wei P, Yang Y, Zhang G, Tian G, Xu Z, acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion. Cell Death Dis, 16(1):23(2025) [pubmed]

10.1038/s41419-025-07345-1;

Feng C, Kong D, Tong B, Liang Y, Xu F, Yang Y, Wu Y, Chi X, Wei P, Yang Y, Zhang G, Tian G, Xu Z, acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion. Cell Death Dis, 16(1):23(2025) [pubmed]

Keyword List

submitter keyword: LC-MS,Clear cell renal carcinoma cell, kidney, ERRα

submitter keyword: LC-MS,Clear cell renal carcinoma cell, kidney, ERRα

Contact List

Feng Chun
contact affiliation	Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
contact email	Fengchun0816@163.com
lab head
Chun Feng
contact affiliation	Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment,Yantai, China. The Second Medical College, Binzhou Medical University, Yantai, China.
contact email	Fengchun0816@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD041739
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD041739

PRIDE project URI

Repository Record List

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