PXD041733-1
PXD041733 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Analysis of the Urothelial Cancer Landscape |
Description | Urothelial cancer is a challenging disease with a wide tumor-biological spec-trum. Most molecular classification attempts are transcriptome-based and re-late only indirectly to the therapeutically relevant protein level. We improve preanalytical preparation of clinical samples for proteome analyses and char-acterize a comprehensive cohort of 434 samples with 242 tumors and 192 paired normal mucosae. We evaluate sample-wise tumor specificity and rank biomarkers by target relevance. We identify five tumor clusters that add prog-nostic information independent from histopathological groups. In silico drug prediction suggests efficacy of several compounds hitherto not in clinical use. Both, in silico as well as in vitro data, indicate predictive value of the proteo-mic clusters for these drugs. Comparative validation on external transcriptom-ic data confirms prognostic relevance and contextualizes proteomic and tran-scriptomic classifications. A real-world diagnostic approach based on im-munohistochemistry further validates our proteomic data but underlines the necessity of omics scale molecular analyses for personalized oncology. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-16 |
AnnouncementXML | Submission_2024-06-15_23:16:35.322.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hannah Voß |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-04-22 08:33:09 | ID requested | |
⏵ 1 | 2024-06-15 23:16:36 | announced |
Publication List
Dressler FF, Diedrichs F, Sabtan D, Hinrichs S, Krisp C, Gemoll T, Hennig M, Mackedanz P, Schlotfeldt M, Vo, ß H, Offermann A, Kirfel J, Roesch MC, Struck JP, Kramer MW, Merseburger AS, Gratzke C, Schoeb DS, Miernik A, Schl, ü, ter H, Wetterauer U, Zubarev R, Perner S, Wolf P, V, é, gv, á, ri Á, Proteomic analysis of the urothelial cancer landscape. Nat Commun, 15(1):4513(2024) [pubmed] |
10.1038/s41467-024-48096-5; |
Keyword List
submitter keyword: Proteome Analysis,Urothelial Cancer, Multi-Cernter Study, Personalized Oncology, Data integration |
Contact List
Franz F. Dressler | |
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contact affiliation | Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany |
contact email | franz-friedrich.dressler@charite.de |
lab head | |
Hannah Voß | |
contact affiliation | University Medical Center Hamburg Eppendorf, Institute of Clinical Chemistry and Laboratory Medicine, Group of Mass Spectrometric Proteomics |
contact email | ha.voss@uke.de |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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