PXD041690 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | O-Glycosylation of Mycobacteriophage Proteins |
Description | Provided herein is the first evidence that mycobacteriophage, indeed phage of any kind, have surface proteins (capsid and/or tail tube proteins) that are O-glycosylated. The glycosyltranferases that glycosylate these proteins are encoded in the phage genomes. In addition, for the three mycobacteriophages invested in this study, the glycans appear to be attached exclusively at a C-terminal serine residue. Each phage expresses a unique and novel O-glycan. The LC-MS files deposited here are the preliminary evidence that these mycobacteriophage proteins are glycosylated. A follow-up investigation will examine the composition and structure of the O-glycans in more detail. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-10 |
AnnouncementXML | Submission_2024-08-10_12:05:42.927.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD041690 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | John Kelly |
SpeciesList | scientific name: Mycobacterium phage Myrna; NCBI TaxID: 546805; scientific name: Mycobacterium phage Corndog; NCBI TaxID: 2907833; scientific name: Mycobacterium phage Che8; NCBI TaxID: 2907829; |
ModificationList | complex glycosylation |
Instrument | Orbitrap Eclipse; Q-Tof Premier; Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-20 09:39:13 | ID requested | |
⏵ 1 | 2024-08-10 12:05:43 | announced | |
Publication List
10.1016/j.chom.2023.05.028; |
Freeman KG, Robotham AC, Parks OB, Abad L, Jacobs-Sera D, Lauer MJ, Podgorski JM, Zhang Y, Williams JV, White SJ, Kelly JF, Hatfull GF, Pope WH, Virion glycosylation influences mycobacteriophage immune recognition. Cell Host Microbe, 31(7):1216-1231.e6(2023) [pubmed] |
10.6019/PXD041690; |
Keyword List
submitter keyword: O-glycosylation, Tail Tube Protein,Mycobacteriophage, Capsid |
Contact List
John Kelly |
contact affiliation | Human Health Therapeutics, National Research Council of Canada |
contact email | John.Kelly@nrc-cnrc.gc.ca |
lab head | |
John Kelly |
contact affiliation | Human Health Therapeutics, National Research Council of Canada |
contact email | John.Kelly@nrc-cnrc.gc.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD041690 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041690
- Label: PRIDE project
- Name: O-Glycosylation of Mycobacteriophage Proteins