PXD041689-1

PXD041689 is an original dataset announced via ProteomeXchange.

Title	Fibrotic Response to anti-CSF-1R Treatment Potentiates Glioblastoma Recurrence
Description	Treatment of glioblastoma with anti-CSF-1R immunotherapy, radiotherapy, or surgical tumor resection were found to all induce a fibrotic response to treatment, which was highly associated with tumor recurrence. To investigate the drivers of fibrotic treatment response we performed multi-omic analysis of the glioblastoma microenvironment following treatment with anti-CSF-1R immunotherapy. Studies consisted of mass spectrometry proteomic analysis, single cell transcriptomics, and high-dimensional spatial analysis. These data identified a protective spatial niche that supported tumor cell survival following treatment, ultimately leading to tumor recurrence. Therapeutic inhibition of fibrotic treatment response blocked the formation of this niche, and significantly improved survival in anti-CSF-1R preclinical trials
HostingRepository	PRIDE
AnnounceDate	2024-08-12
AnnouncementXML	Submission_2024-08-12_04:08:49.937.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfredo Quadroni
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-20 09:05:31	ID requested
⏵ 1	2024-08-12 04:08:50	announced
2	2024-10-22 06:54:42	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: multi-omic, recurrence,Glioblastoma, fibrosis, immunotherapy

Johanna Joyce
contact affiliation	Department of Oncology, University of Lausanne, Lausanne, Switzerland
contact email	johanna.joyce@unil.ch
lab head
Manfredo Quadroni
contact affiliation	University of Lausanne
contact email	manfredo.quadroni@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD041689

PRIDE project URI

• PRIDE
  1. PXD041689
     1. Label: PRIDE project
     2. Name: Fibrotic Response to anti-CSF-1R Treatment Potentiates Glioblastoma Recurrence