PXD041665 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in in mice and humans |
Description | The meninges of the brain are an important component of neuroinflammatory response. Diverse immune cells move from the calvaria marrow into the dura mater via recently discovered skull-meninges connections (SMCs). However, how the calvaria bone marrow is different from the other bones and whether and how it contributes to human diseases remain unknown. Using multi-omics approaches and whole mouse transparency we reveal that bone marrow cells are highly heterogeneous across the mouse body. The mouse calvaria and the human skull harbors the most distinct molecular signature with hundreds of differentially expressed genes and proteins when compared to other bones. Our study indicates that the calvaria is more than a physical barrier, and its immune cells may present new ways to control brain pathologies. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_06:49:26.258.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Saketh Kapoor |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | timsTOF SCP |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-19 17:58:10 | ID requested | |
1 | 2023-07-29 09:06:46 | announced | |
⏵ 2 | 2023-11-14 06:49:26 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Calvaria, Meninges, Brain, timsTOF SCP, Proteomics |
Contact List
Prof. Dr. |
contact affiliation | Institute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München Ingolstädter Landstraße 1 85764 Neuherberg Germany |
contact email | ali.ertuerk@med.uni-muenchen.de |
lab head | |
Saketh Kapoor |
contact affiliation | Dr. Saketh Kapoor, Ph.D. Mass Spectrometry Unit In-Charge Institute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München Ingolstädter Landstraße 1 85764 Neuherberg Germany +49 15129916548 saketh.kapoor@helmholtz-munich.de http://erturk-lab.com/team/ |
contact email | saketh.kapoor@helmholtz-munich.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041665
- Label: PRIDE project
- Name: Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in in mice and humans