PXD041605 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | OGA-mediated protein glycosylation regulates pluripotency states in human embryonic stem cells |
| Description | In our previous study, we uncovered that OGA significantly elevated in naïve hESC. Therefore, we sought to investigate the effects of O-GlcNAc on hESC and the interconvert of both pluripotent states. Depletion of OGA, which results in global O-GlcNAcylation increased, would impair naïve hESC pluripotency but can promote naïve to primed hESC transition. In addition, we obtained the profiles of O-GlcNAcylated proteins in H9 primed hESC and H9-PXGL hESC via MS based-quantitative proteomics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-08-10 |
| AnnouncementXML | Submission_2024-08-10_12:03:33.240.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiya Fan |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | dimethylated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-04-17 21:10:33 | ID requested | |
| ⏵ 1 | 2024-08-10 12:03:34 | announced | |
| 2 | 2024-10-22 06:54:13 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1016/j.stemcr.2024.05.009; |
| Liu Q, Chen C, Fan Z, Song H, Sha Y, Yu L, Wang Y, Qin W, Yi W, O-GlcNAcase regulates pluripotency states of human embryonic stem cells. Stem Cell Reports, 19(7):993-1009(2024) [pubmed] |
Keyword List
| submitter keyword: human embryonic stem cells，OGA，O-GlcNAc |
Contact List
| Qin Weijie |
|---|
| contact affiliation | National Center for Protein Science, Beijing |
| contact email | aunp_dna@126.com |
| lab head | |
| Zhiya Fan |
|---|
| contact affiliation | National Center for Protein Sciences (Beijing) |
| contact email | zyfan7@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD041605 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041605
- Label: PRIDE project
- Name: OGA-mediated protein glycosylation regulates pluripotency states in human embryonic stem cells
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