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PXD041583-3

PXD041583 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtein expression profiling in eggs and embryos from control and Eif4e1b knockout female mice.
DescriptionWe have identified eukaryotic translation initiation factor 4E family member 1B (Eif4e1b) as a regulator of maternal RNA translation, whose maternal deletion leads to 2-cell arrest phenotype in mouse embryos. eIF4E1b protein binds mRNA selectively in oocytes and controls their translation in early embryos. We aim to profile the global changes in protein expression in metaphase II (MII) eggs and zygotes collected from control or Eif4e1b knockout female mice. An encapsulated proteomic-sample processing protocol is used to perform this low-input mass spectrometry to quantify proteomic changes (Kulak et al. 2014/PMID 24497582).
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:47:49.193.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD041583
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDavid Anderson
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-17 06:31:11ID requested
12023-06-12 05:16:52announced
22023-11-14 09:00:43announced2023-11-14: Updated project metadata.
32024-10-22 05:47:50announced2024-10-22: Updated project metadata.
Publication List
10.1101/gad.350400.123;
10.6019/PXD041583;
Yang G, Xin Q, Feng I, Wu D, Dean J, Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Genes Dev, 37(9-10):418-431(2023) [pubmed]
Keyword List
submitter keyword: Mouse,fertilization, expression profiling,embryo, oocyte
Contact List
Jurrien Dean
contact affiliationLaboratory of Cellular and Developmental Biology, NIDDK, NIH, US GOVERNMENT.
contact emailjurrien.dean@nih.gov
lab head
David Anderson
contact affiliationNIH/NIDDK
contact emaildavida@mail.nih.gov
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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