PXD041583-3
PXD041583 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Protein expression profiling in eggs and embryos from control and Eif4e1b knockout female mice. |
Description | We have identified eukaryotic translation initiation factor 4E family member 1B (Eif4e1b) as a regulator of maternal RNA translation, whose maternal deletion leads to 2-cell arrest phenotype in mouse embryos. eIF4E1b protein binds mRNA selectively in oocytes and controls their translation in early embryos. We aim to profile the global changes in protein expression in metaphase II (MII) eggs and zygotes collected from control or Eif4e1b knockout female mice. An encapsulated proteomic-sample processing protocol is used to perform this low-input mass spectrometry to quantify proteomic changes (Kulak et al. 2014/PMID 24497582). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:47:49.193.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD041583 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | David Anderson |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-04-17 06:31:11 | ID requested | |
1 | 2023-06-12 05:16:52 | announced | |
2 | 2023-11-14 09:00:43 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 05:47:50 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1101/gad.350400.123; |
10.6019/PXD041583; |
Yang G, Xin Q, Feng I, Wu D, Dean J, Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Genes Dev, 37(9-10):418-431(2023) [pubmed] |
Keyword List
submitter keyword: Mouse,fertilization, expression profiling,embryo, oocyte |
Contact List
Jurrien Dean | |
---|---|
contact affiliation | Laboratory of Cellular and Developmental Biology, NIDDK, NIH, US GOVERNMENT. |
contact email | jurrien.dean@nih.gov |
lab head | |
David Anderson | |
contact affiliation | NIH/NIDDK |
contact email | davida@mail.nih.gov |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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