PXD041535 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics Study and Protein Biomarkers of Malignant Ventricular Arrhythmia in Acute Myocardial Infarction Patients |
Description | Acute myocardial infarction (AMI) is one of the leading causes of death. It is particularly important to predict malignant ventricular arrhythmia (MVA) timely and accurately in patients with AMI. This study aimed to explore biomarkers and to reveal possible mechanisms of MVA in AMI for clinical diagnosis. Blood samples from 190 human subjects were collected to reveal the differentially expressed proteins (DEPs) in three comparisons (AMI/control, AMI+MVA/control, and AMI+MVA/AMI) in proteomics with bioinformatics analysis and validated in new cohorts. The diagnostic value of candidate DEPs predicting AMI+MVA was also evaluated by the receiver operating characteristic curve (ROC). A total of 8,365 peptides and 460 proteins from the LC-MS/MS analysis were identified with 90 in AMI/control, 94 in AMI+MVA/control, and 43 in AMI+MVA/AMI identified as DEPs. TGFBI level had notable decreasing trend in AMI+MVA (161.9 ± 19.0 ng/ml) compared with AMI (P<0.0001) or control (P<0.0001). vWF level in AMI+MVA patients was significantly higher than that in AMI patients (P<0.01) and control (P<0.0001). ROC analysis showed that TGFBI and vWF had the strong and potential value of predicting MVA in AMI. By constructing proteomics profile to identify the protein characteristics this study found that decreased TGFBI and increased vWF are the characteristics of proteins in the MVA patients with AMI. These findings provide new insight into the diagnosis and pathogenesis of the development of MVA. Further, decreased TGFBI and increased vWF are potential predicting biomarkers for diagnosis of MVA in AMI patients. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-26 |
AnnouncementXML | Submission_2024-01-26_12:56:53.098.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hai-Tao Hou |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-14 04:06:37 | ID requested | |
⏵ 1 | 2024-01-26 12:56:53 | announced | |
Publication List
Zhang JL, Hou HT, Song Y, Guo M, Liu XC, Yang Q, He GW, Proteomics study and protein biomarkers of malignant ventricular arrhythmia in acute myocardial infarction patients. Clin Transl Med, 13(11):e1435(2023) [pubmed] |
10.1002/ctm2.1435; |
Keyword List
submitter keyword: Acute myocardial infarction |
malignant ventricular arrhythmia |
proteomics |
data independent acquisition |
Contact List
Hou Hai Tao |
contact affiliation | The Institute of Cardiovascualr Diseases &Department of Cardiovascular surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Graduate School of Peking Union Medical College &Tianjin University, Tianjin, China |
contact email | hhtpk007@163.com |
lab head | |
Hai-Tao Hou |
contact affiliation | Teda International Cardiovascular Hospital |
contact email | hhtpk007@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041535
- Label: PRIDE project
- Name: Proteomics Study and Protein Biomarkers of Malignant Ventricular Arrhythmia in Acute Myocardial Infarction Patients