PXD041515 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multiomic temporal landscape of plasma and synovial fluid derived extracellular vesicles using an experimental model of equine osteoarthritis |
| Description | Osteoarthritis (OA) is the most common equine joint disease characterised by cartilage degradation and changes to other joint tissues severely effecting welfare and performance leading to early retirement. It results in substantial morbidity and mortality, but our understanding of the pathophysiological mechanisms involved is limited. There are no disease modifying therapeutics available, with OA medication offering symptomatic relief only. Early diagnosis is thus important, as substantial joint pathology is usually present at the time of clinical diagnosis. Thus, biomarkers of early-stage OA are actively sought, and among these, extracellular vesicles (EVs) are emerging as potential candidates. Here we use a SWATH MS approach to profile the protein cargo of EVs derived from equine plasma and synovial fluid. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_09:12:38.644.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rosalind Jenkins |
| SpeciesList | scientific name: Equus caballus (Horse); NCBI TaxID: 9796; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-04-13 06:32:57 | ID requested | |
| 1 | 2023-10-24 13:42:39 | announced | |
| ⏵ 2 | 2023-11-14 09:12:40 | announced | 2023-11-14: Updated project metadata. |
Publication List
| Anderson JR, Johnson E, Jenkins R, Jacobsen S, Green D, Walters M, Bundgaard L, Hausmans BAC, van den Akker G, Welting TJM, Chabronova A, Kharaz YA, Clarke EJ, James V, Peffers MJ, Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis. Int J Mol Sci, 24(19):(2023) [pubmed] |
Keyword List
| submitter keyword: proteins,osteoarthritis, extracellular vesicles, plasma, small non-coding RNA, synovial fluid |
Contact List
| Rosalind Elspeth Jenkins |
|---|
| contact affiliation | CDSS Bioanalytical Facility, LIV-SRF, Dept. Pharmacology & Therapeutics, Institute for Systems, Molecular and Integrative Biology, University of Liverpool |
| contact email | R.Jenkins@liv.ac.uk |
| lab head | |
| Rosalind Jenkins |
|---|
| contact affiliation | University of Liverpool |
| contact email | R.Jenkins@liv.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041515
- Label: PRIDE project
- Name: Multiomic temporal landscape of plasma and synovial fluid derived extracellular vesicles using an experimental model of equine osteoarthritis
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