PXD041419-1

PXD041419 is an original dataset announced via ProteomeXchange.

Title	Proteomics and machine learning identify a distinct blood biomarker panel to detect Parkinson’s disease up to 7 years before motor disease
Description	Parkinson’s disease (PD) is increasing in prevalence, yet we lack readily available and non-invasive diagnostic biomarkers. An unbiased discovery proteomics study in plasma from PD patients and healthy controls (HC, phase 0) showed increased inflammation and decreased Wnt-signalling. To validate these findings, a targeted and multiplexed assay was developed and applied to a phase I cohort consisting of 99 de novo PD, 36 HC, and 18 subjects with polysomnography-confirmed isolated REM-sleep behaviour disorder (iRBD). In phase II, the multiplexed panel was refined and applied to a second cohort, focusing on the earliest stage of the disease by analysing 54 individuals with confirmed iRBD including longitudinal follow-up samples. A machine learning model, based on the expression of eight proteins, correctly identified all PD patients (phase I) and classified 79% of the iRBD as PD (phase II) up to 7 years before phenoconversion. Several of the identified biomarkers correlated with motor and non-motor symptom severity. This specific blood pattern was already evident in most iRBD cases, indicating pre-motor molecular events. This allows for the early identification of subjects at risk for PD in a blood test years before motor disease, which could support stratifying participants in future clinical trials aimed at preventing PD.
HostingRepository	PanoramaPublic
AnnounceDate	2024-03-12
AnnouncementXML	Submission_2024-03-12_20:33:57.842.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jenny Hallqvist
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl
Instrument	Xevo TQ MS; ACQUITY UPLC

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-09 15:45:39	ID requested
⏵ 1	2024-03-12 20:33:58	announced

Dataset with its publication pending

submitter keyword: LC-MS, MRM, Targeted proteomics, Biomarkers, Parkinson's disease, Neurodegeneration

Kevin Mills
contact affiliation	Great Ormond Street Institute of Child Health, University College London
contact email	k.mills@ucl.ac.uk
lab head
Jenny Hallqvist
contact affiliation	Great Ormond Street Institute of Child Health, University College London
contact email	j.hallqvist@ucl.ac.uk
dataset submitter

Panorama Public dataset URI