PXD041355-2

PXD041355 is an original dataset announced via ProteomeXchange.

Title	Identification of an outer membrane protease of Rickettsia rickettsii responsible for maturation of surface exposed autotransporters
Description	Strains of R. rickettsii, the agent of Rocky Mountain spotted fever, differ greatly in the severity of the disease caused. The genetic differences responsible for this disparity are only now being uncovered. An avirulent, laboratory adapted strain of R. rickettsii fails to proteolytically process several large surface protein antigens. We have identified a protease that cleaves the protein precursors to their mature form. The gene encoding this protease is mutated in the avirulent strain. Complementation of the active form of the gene identifies proteolytic processing of surface antigens as important to virulence.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:52:23.483.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yixiang Zhang
SpeciesList	scientific name: Rickettsia rickettsii str. 'Sheila Smith'; NCBI TaxID: 392021; scientific name: Rickettsia rickettsii str. Iowa; NCBI TaxID: 452659;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-05 09:43:50	ID requested
1	2023-07-06 13:02:30	announced
⏵ 2	2024-10-22 05:52:23	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: autotransporter,Rickettsia rickettsii

Ted Hackstadt
contact affiliation	Host-Parasite Interactions Section, RML/NIAID/NIH
contact email	ted.hackstadt@nih.gov
lab head
Yixiang Zhang
contact affiliation	RML/NIAID/NIH
contact email	alexzhangyx@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041355
     1. Label: PRIDE project
     2. Name: Identification of an outer membrane protease of Rickettsia rickettsii responsible for maturation of surface exposed autotransporters