PXD041354-2

PXD041354 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	INTERACTOME ANALYSIS IDENTIFIES THE ROLE OF BZW2 IN PROMOTING ENDOPLASMIC RETICULUM-MITOCHONDRIAL CONTACT AND MITOCHONDRIAL METABOLISM
Description	Maio et. al. presents a comprehensive and quantitative interactome of BZW2, a protein found to promote human cancers with little known about its molecular function. Many of the proteins identified were either mitochondrial or endoplasmic reticulum (ER) proteins, suggesting BZW2 may play a role in mitochondria-ER contact. We found that BZW2 indeed localizes to and promotes the formation of mitochondria-ER contact sites (MERCS), thus promoting calcium transport from ER to the mitochondria and promotes mitochondrial ATP production. These findings provide key insights into molecular functions of BZW2, the potential role of BZW2 in cancer progression, and highlights the utility of interactome data in understanding the function of less-studied proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:28.933.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sheng Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-05 09:01:12	ID requested
1	2024-05-24 02:05:51	announced
⏵ 2	2024-10-22 06:42:34	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/j.mcpro.2023.100709;
Maio G, Smith M, Bhawal R, Zhang S, Baskin JM, Li J, Lin H, Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism. Mol Cell Proteomics, 23(2):100709(2024) [pubmed]

10.1016/j.mcpro.2023.100709;

Maio G, Smith M, Bhawal R, Zhang S, Baskin JM, Li J, Lin H, Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism. Mol Cell Proteomics, 23(2):100709(2024) [pubmed]

Keyword List

submitter keyword: MERCS, lipid metabolism., mitochondrial metabolism, MAM, calcium,BZW2, interactome

submitter keyword: MERCS, lipid metabolism., mitochondrial metabolism, MAM, calcium,BZW2, interactome

Contact List

Sheng Zhang
contact affiliation	Cornell University
contact email	sz14@cornell.edu
lab head
Sheng Zhang
contact affiliation	Cornell University
contact email	sz14@cornell.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD041354
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD041354

PRIDE project URI

Repository Record List

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