<<< Full experiment listing


PXD041349 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDll4iDEC mouse liver endothelial cells
DescriptionMyc and its target Odc1 were among the most 250 strongly upregulated genes in Dll4 mutant ECs, compared with Notch1 and Rbpj mutants. Myc is known to activate important ribosome biogenesis and protein translation pathways, favoring cell growth. Dll4iDEC livers showed upregulation of a large range of canonical E2F, Myc, and mTORC1 target genes and ribosomal genes, particularly in the activated, proliferating, and endothelial tip-cell clusters. This hypermetabolic transcriptional status was confirmed by in-depth proteomics analysis of protein lysates obtained from freshly isolated liver ECs, providing the first proteomics analysis of the endothelial tip-cell state induced by targeting Dll4.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiTRAQ8plex-116 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-05 04:57:52ID requested
12023-04-11 03:14:25announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Dll4iDEC liver endothelial cells, quantitative proteomics
Contact List
contact affiliationCardiovascular Proteomics Laboratory & Proteomics Unit Centro Nacional de Investigaciones Cardiovasculares Madrid, Spain
contact emailjesus.vazquez@cnic.es
lab head
contact affiliationProteomics Unit Vascular Pathophysiology Area CNIC
contact emailecamafeita@cnic.es
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD041349
PRIDE project URI
Repository Record List
[ + ]