PXD041333-2

PXD041333 is an original dataset announced via ProteomeXchange.

Title	Uncovering diurnal rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder
Description	This article presents a study that examines the proteomic alterations associated with opioid use disorder (OUD) in the human brain. The study investigates the interplay between pro-inflammatory signaling, extracellular matrix (ECM) remodeling, and synaptic plasticity in the corticostriatal circuitry associated with OUD. The findings reveal differential alterations in the synaptic proteomes across the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC), indicating that changes in certain synaptic subtypes are unique to each brain region. The proteomic alterations associated with OUD in DLPFC are mainly in glutamatergic, serotonergic, dopaminergic, and oxytocin signaling, while altered adrenergic signaling is enriched in NAc. The study also identifies alterations in proteins involved in circadian entrainment specifically in synaptic enrichments in both DLPFC and NAc of OUD subjects. These findings provide new evidence linking disrupted molecular rhythms in the regulation of distinct synaptic subtypes altered by opioids.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:13:35.471.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041333
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew MacDonald
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-04 10:31:58	ID requested
1	2023-10-25 08:47:25	announced
⏵ 2	2023-11-14 09:13:39	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:13:24	announced	2024-10-22: Updated project metadata.

Puig S, Xue X, Salisbury R, Shelton MA, Kim SM, Hildebrand MA, Glausier JR, Freyberg Z, Tseng GC, Yocum AK, Lewis DA, Seney ML, MacDonald ML, Logan RW, Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens. Mol Psychiatry, 28(11):4777-4792(2023) [pubmed]

10.6019/PXD041333;

submitter keyword: Human, dorsolateral prefrontal cortex, nucleus accumbens, Postmortem Brain Tissue,Opiods

Matthew L MacDonald
contact affiliation	Department of Psychiatry, University of Pittsburgh
contact email	mlmacdonald@gmail.com
lab head
Matthew MacDonald
contact affiliation	University of Pittsburgh
contact email	mlmacdonald@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041333
     1. Label: PRIDE project
     2. Name: Uncovering diurnal rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder