PXD041332-2

PXD041332 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Inhibitory and Excitatory Synaptic Neuroadaptations in the diazepam tolerant brain
Description	Benzodiazepine (BZ) drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by potentiating γ2 subunit containing GABA type A receptors (GABAARs). BZ clinical use is hampered by tolerance and withdrawal symptoms, which include heightened seizure susceptibility, panic, and sleep disturbances. Here, we undergo a comprehensive investigation of inhibitory GABAergic and excitatory glutamatergic plasticity in mice tolerant to benzodiazepine sedation. Using quantitative proteomics approaches, we reveal cortex neuroadaptations of key pro-excitatory mediators and synaptic plasticity pathways, highlighted by Ca2+/calmodulin-dependent protein kinase II (CAMKII), MAPK, and PKC signaling.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:09:33.192.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041332
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Tija Jacob
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-04 09:33:25	ID requested
1	2023-10-24 12:34:40	announced
⏵ 2	2023-11-14 09:09:41	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:09:59	announced	2024-10-22: Updated project metadata.

Publication List

Lorenz-Guertin JM, Povysheva N, Chapman CA, MacDonald ML, Fazzari M, Nigam A, Nuwer JL, Das S, Brady ML, Vajn K, Bambino MJ, Weintraub ST, Johnson JW, Jacob TC, Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain. Neurobiol Dis, 185():106248(2023) [pubmed]
10.6019/PXD041332;

Lorenz-Guertin JM, Povysheva N, Chapman CA, MacDonald ML, Fazzari M, Nigam A, Nuwer JL, Das S, Brady ML, Vajn K, Bambino MJ, Weintraub ST, Johnson JW, Jacob TC, Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain. Neurobiol Dis, 185():106248(2023) [pubmed]

10.6019/PXD041332;

Keyword List

submitter keyword: Mouse, Brain, TMT MS

submitter keyword: Mouse, Brain, TMT MS

Contact List

Tija Jacob
contact affiliation	Department of Pharmacology & Chemical Biology W1351 Thomas Starzl Biomedical Science Tower, 200 Lothrop St,Pittsburgh, PA 15261
contact email	tcj11@pitt.edu
lab head
Tija Jacob
contact affiliation	University of Pittsburgh School of Medicine
contact email	tcj11@pitt.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD041332
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD041332

PRIDE project URI

Repository Record List

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