PXD041256 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeted delivery of tumor necrosis factor in combination with lomustine induces a T-cell dependent regression of glioblastoma |
Description | Glioblastoma is the most aggressive primary brain tumor with an unmet need for more effective therapies. Here we report that the combination of L19TNF, an antibody-cytokine fusion protein based on tumor necrosis factor that selectively localizes on the tumor neo-vasculature, with the alkylating agent lomustine, can induce tumor regression in orthotopic glioma-bearing mice and patients with recurrent glioblastoma. Mechanistically, this striking synergy crucially depended on T cells and involved activation of the tumor endothelium, tumor DNA damage, treatment-associated tumor necrosis, increased antigen presentation on MHC class I and tumor immune cell infiltration, as well as decreased tumor-associated immunosuppression. The clinical translation of this approach is ongoing, but already shows durable responses in the first recurrent glioblastoma patient cohort treated with L19TNF in combination with lomustine (NCT04573192). |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:00:23.381.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD041256 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Domenico Ravazza |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-31 08:37:23 | ID requested | |
1 | 2023-06-01 02:13:16 | announced | |
⏵ 2 | 2023-11-14 09:00:23 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: immunotherapy MHC-I,immunopeptidomics |
Contact List
Ettore Gilardoni |
contact affiliation | Philochem AG,Libernstrasse 3, 8112 Otelfingen, Switzerland |
contact email | ettore.gilardoni@philochem.ch |
lab head | |
Domenico Ravazza |
contact affiliation | Philochem AG |
contact email | domenico.ravazza@philochem.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041256
- Label: PRIDE project
- Name: Targeted delivery of tumor necrosis factor in combination with lomustine induces a T-cell dependent regression of glioblastoma