PXD041255-1

PXD041255 is an original dataset announced via ProteomeXchange.

Title	Transcriptomic and Proteomic Profiling Reveal Immune and Metabolic Dysregulation in the Colonic Mucosa of People with HIV with Incomplete Immune Recovery
Description	Background: People living with HIV are called immunological non-responders (INR) when their CD4+ T cell count is not restored to immunocompetent levels, despite successful viral suppression. INR have increased risk of progression to AIDS, non-AIDS related morbidity, and death. Impaired mucosal barrier function is a prevailing hypothesis for why INR among people with HIV (PWH) have persistently low CD4+ T cell counts. Objective: To understand the molecular mechanisms behind incomplete immune recovery in INR, we analysed gene regulation and protein expression in gut tissues from INR, immunological responders (IR), and healthy controls (HC).
HostingRepository	PRIDE
AnnounceDate	2025-09-09
AnnouncementXML	Submission_2025-09-09_09:14:50.928.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Animesh Sharma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deaminated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-31 08:26:04	ID requested
⏵ 1	2025-09-09 09:14:51	announced

10.3389/FIMMU.2025.1635523;

submitter keyword: HIV, immunological non-responders, mucosal immunology

Mari Kaarbø
contact affiliation	Group Leader, Department of Microbiology, Oslo University Hospital. Norway, Tel: +47 230 13906
contact email	mari.kaarbo@rr-research.no
lab head
Animesh Sharma
contact affiliation	Engineer at NTNU, Norway
contact email	sharma.animesh@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD041255

PRIDE project URI

• PRIDE
  1. PXD041255
     1. Label: PRIDE project
     2. Name: Transcriptomic and Proteomic Profiling Reveal Immune and Metabolic Dysregulation in the Colonic Mucosa of People with HIV with Incomplete Immune Recovery