PXD041234 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeted delivery of tumor necrosis factor in combination with lomustine induces a T-cell dependent regression of glioblastoma |
| Description | Glioblastoma is the most aggressive primary brain tumor with an unmet need for more effective therapies. Here we report that the combination of L19TNF, an antibody-cytokine fusion protein based on tumor necrosis factor that selectively localizes on the tumor neo-vasculature, with the alkylating agent lomustine, can induce tumor regression in orthotopic glioma-bearing mice and patients with recurrent glioblastoma. Mechanistically, this striking synergy crucially depended on T cells and involved activation of the tumor endothelium, tumor DNA damage, treatment-associated tumor necrosis, increased antigen presentation on MHC class I and tumor immune cell infiltration, as well as decreased tumor-associated immunosuppression. The clinical translation of this approach is ongoing, but already shows durable responses in the first recurrent glioblastoma patient cohort treated with L19TNF in combination with lomustine (NCT04573192). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-23_03:02:42.800.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Marcel Bühler |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-03-31 00:23:36 | ID requested | |
| ⏵ 1 | 2026-02-23 03:02:43 | announced | |
Publication List
| 10.3389/fpls.2025.1740888; |
| Morcillo M, Sanchez-Lucas R, Sales E, Jorr, í, n-Novo J, Miedes E, Arrillaga I, in holm oak embryogenic lines. Front Plant Sci, 16():1740888(2025) [pubmed] |
Keyword List
| submitter keyword: Immunocytokine, Glioblastoma, Proteomics, Immunotherapy |
Contact List
| Tobias Weiss |
|---|
| contact affiliation | Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich; Zurich, Switzerland |
| contact email | tobias.weiss@usz.ch |
| lab head | |
| Marcel Bühler |
|---|
| contact affiliation | Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland |
| contact email | marcel.buehler3@uzh.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD041234 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041234
- Label: PRIDE project
- Name: Targeted delivery of tumor necrosis factor in combination with lomustine induces a T-cell dependent regression of glioblastoma
