PXD041210-1

PXD041210 is an original dataset announced via ProteomeXchange.

Title	Statin attenuates Wnt/β-catenin signaling by targeting the SATB family of proteins in Colorectal cancer
Description	Amongst varied cancers, colorectal cancer (CRC) is the second highest cause for mortality worldwide, suggesting inefficacy of existing medications. Thereby, justifying the need for extensive research to delineate the molecular mechanisms, and evolve new therapies. It has been well established that one of the major pathways responsible for adenoma formation in CRC is the aberrant Wnt/β-catenin signaling. The constant unearthing of it’s molecular players has contributed to a deeper understanding of tumor progression and prognosis, increasing the horizon for targeted therapeutics. One of the methodologies adopted is the repurposing of drugs that target a physiological pathway, known to be dysregulated in tumorigenesis. Hypercholesterolemia has been associated with high-risk CRC patients exclusively, making statins a potential drug for trials in human subjects. Statins are a well-established family of drugs that selectively inhibit de novo cholesterol biosynthesis causing a reduction in systemic cholesterol levels in dyslipidemia. We have contributed to building evidence of statin's anti-tumor activity in both in vitro and in vivo. Our multi-pronged approach provides a holistic view of statin treatment at the lipid, transcript, and protein levels. Interestingly, we observe the Wnt/ β-catenin signaling players getting targeted, one of the most important being SATB (Special AT-rich Binding protein) proteins. Previously, we established the role of SATB1 in tumorigenesis, regulated by β-catenin in Wnt “ON” conditions. On the other hand, SATB2, belonging to the same family, has been reported playing an opposite role. We show that Statins target the physiological balance between the two proteins by downregulating SATB1 and upregulating SATB2. Our phase II trial study in CRC patients further strengthens our hypothesis regarding the differential expression of SATB proteins as a key in determining the tumorigenic outcome. Collectively, these results establish that this molecular switch could provide new therapeutic possibilities in the future, by repurposing statins.
HostingRepository	PRIDE
AnnounceDate	2025-06-24
AnnouncementXML	Submission_2025-06-23_22:07:36.645.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Siddhesh Kamat
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-30 04:32:06	ID requested
⏵ 1	2025-06-23 22:07:37	announced

Dataset with its publication pending

submitter keyword: Human, Statin, Colon Cancer

Siddhesh S. Kamat
contact affiliation	Department of Biology, IISER Pune
contact email	siddhesh@iiserpune.ac.in
lab head
Siddhesh Kamat
contact affiliation	Indian Institute of Science Education and Research Pune
contact email	siddhesh@iiserpune.ac.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041210
     1. Label: PRIDE project
     2. Name: Statin attenuates Wnt/β-catenin signaling by targeting the SATB family of proteins in Colorectal cancer