PXD041174 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Smooth Muscle Cell Phenotypic Switch Induced by Cigarette Smoke Condensate |
Description | Cigarette smoke is a risk factor for inflammatory diseases, such as atherosclerosis. Tobacco smoke interacts with inflammatory cytokines to produce endothelial dysfunction and induces pro-inflammatory and pro-atherosclerotic effects in vascular tissue. Smooth muscle cells (SMCs) are present in the media of human arteries, and are considered protective against atherosclerotic plaque destabilization. Contractile SMCs are the most prominent cell type in the healthy vessel wall. SMCs are not terminally differentiated, and retain the ability to undergo a phenotypic switch from a contractile to a dedifferentiated synthetic state to express inflammatory markers and a phagocytic activity in response to environmental cues. The aim of our study was to evaluate the effects in human SMCs of lipophilic component from cigarette smoke condensate (CSC) and of hydrophilic components of Electronic-cigarette, Tobacco heating products, or cigarette smoke. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:47:47.003.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD041174 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Stefano Bellosta |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-28 18:49:07 | ID requested | |
1 | 2023-05-10 15:03:27 | announced | |
⏵ 2 | 2023-11-14 08:47:48 | announced | 2023-11-14: Updated project metadata. |
Publication List
Bianchi L, Damiani I, Castiglioni S, Carleo A, De Salvo R, Rossi C, Corsini A, Bellosta S, Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview. Int J Mol Sci, 24(7):(2023) [pubmed] |
10.6019/PXD041174; |
Keyword List
submitter keyword: Atherosclerosis |
cigarette smoke |
electronic cigarette |
phenotypic switch |
smooth muscle cells |
Contact List
Stefano Bellosta |
contact affiliation | University of Milan, Faculty of Pharmacy, Department of Pharmacological and Biomolecular Science, 20133 Milan, ITALY |
contact email | stefano.bellosta@unimi.it |
lab head | |
Stefano Bellosta |
contact affiliation | Università degli studi di Milano |
contact email | stefano.bellosta@unimi.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041174
- Label: PRIDE project
- Name: Smooth Muscle Cell Phenotypic Switch Induced by Cigarette Smoke Condensate