PXD041143-1
PXD041143 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | S-nitrosylated cysteine residues identification in Staphylococcus aureus XN108 |
| Description | Staphylococcus aureus is a major human pathogen that causes diverse severe infections. The emergence of multi-drug resistance has caused S. aureus infection a global concern, especially resistance to vancomycin, a drug of last resort. A growing body of research focuses on the resistance mechanisms and antibiotic discovery. S-nitrosylation, a posttranslational modification on cysteine thiol mediated by Nitric oxide (NO) has been found to drive a large part of the ubiquitous influence of NO on mediating cellular functions. Several gram-positive microorganisms, including S. aureus, possess a bacterial NO synthase (bNOS) to generate NO endogenously. bNOS was reported to play an important role in protecting bacteria against a wide spectrum of antibiotics, but the precise underlying mechanism remains elusive. Here, S-nitrosylation patterns were analyzed in a clinically isolated vancomycin-intermediate staphylococcus aureus strain XN108 by liquid chromatography-mass spectrometry (LC-MS)/MS. The MS data of samples XN_1 and XN_2 were integrated and analyzed. |
| HostingRepository | iProX |
| AnnounceDate | 2023-03-27 |
| AnnouncementXML | Submission_2023-03-27_19:36:51.849.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xueqin Shu |
| SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-27 19:36:35 | ID requested | |
| ⏵ 1 | 2023-03-27 19:36:52 | announced | |
| 2 | 2023-05-06 00:07:08 | announced | 2023-05-06: Update publication information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: S-nitrosylation, Staphylococcus aureus |
Contact List
| Baolin Sun | |
|---|---|
| contact affiliation | University of Science and Technology of China |
| contact email | sunb@ustc.edu.cn |
| lab head | |
| Xueqin Shu | |
| contact affiliation | University of Science and Technology of China |
| contact email | shirleys@mail.ustc.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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