PXD041143
PXD041143 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | S-nitrosylated cysteine residues identification in Staphylococcus aureus XN108 |
Description | Staphylococcus aureus is a major human pathogen that causes diverse severe infections. The emergence of multi-drug resistance has caused S. aureus infection a global concern, especially resistance to vancomycin, a drug of last resort. A growing body of research focuses on the resistance mechanisms and antibiotic discovery. S-nitrosylation, a posttranslational modification on cysteine thiol mediated by Nitric oxide (NO) has been found to drive a large part of the ubiquitous influence of NO on mediating cellular functions. Several gram-positive microorganisms, including S. aureus, possess a bacterial NO synthase (bNOS) to generate NO endogenously. bNOS was reported to play an important role in protecting bacteria against a wide spectrum of antibiotics, but the precise underlying mechanism remains elusive. Here, S-nitrosylation patterns were analyzed in a clinically isolated vancomycin-intermediate staphylococcus aureus strain XN108 by liquid chromatography-mass spectrometry (LC-MS)/MS. The MS data of samples XN_1 and XN_2 were integrated and analyzed. |
HostingRepository | iProX |
AnnounceDate | 2023-03-27 |
AnnouncementXML | Submission_2023-05-06_00:07:07.557.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xueqin Shu |
SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-03-27 19:36:35 | ID requested | |
1 | 2023-03-27 19:36:52 | announced | |
⏵ 2 | 2023-05-06 00:07:08 | announced | 2023-05-06: Update publication information. |
Publication List
Shu X, Shi Y, Huang Y, Yu D, Sun B, Transcription tuned by S-nitrosylation underlies a mechanism for Staphylococcus aureus to circumvent vancomycin killing. Nat Commun, 14(1):2318(2023) [pubmed] |
Keyword List
submitter keyword: S-nitrosylation, Staphylococcus aureus |
Contact List
Baolin Sun | |
---|---|
contact affiliation | University of Science and Technology of China |
contact email | sunb@ustc.edu.cn |
lab head | |
Xueqin Shu | |
contact affiliation | University of Science and Technology of China |
contact email | shirleys@mail.ustc.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |