PXD041047-1

PXD041047 is an original dataset announced via ProteomeXchange.

Title	ChemBioID - An integrated chemical biology workflow for the analysis of pomalidomide induced target proximity
Description	Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project.
HostingRepository	PRIDE
AnnounceDate	2023-04-25
AnnouncementXML	Submission_2023-04-25_07:25:47.316.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthias Gstaiger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-23 04:59:06	ID requested
⏵ 1	2023-04-25 07:25:47	announced

Dataset with its publication pending

submitter keyword: CRBN, BioID, pomalidomide

MatthiasGstaiger
contact affiliation	Institute of Molecular Systems Biology HPM F43 Otto-Stern-Weg 3 8093 Zürich Switzerland
contact email	gstaigem@ethz.ch
lab head
Matthias Gstaiger
contact affiliation	Institute of Molecular Systems Biology, ETH
contact email	gstaigem@ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD041047

PRIDE project URI

• PRIDE
  1. PXD041047
     1. Label: PRIDE project
     2. Name: ChemBioID - An integrated chemical biology workflow for the analysis of pomalidomide induced target proximity