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PXD040995-1

PXD040995 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleArginine reprograms metabolism in liver cancer via RBM39
DescriptionMetabolic reprogramming is a hallmark of cancer. However, mechanisms underlying metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are poorly understood. Here, we report that arginine levels are elevated in hepatocellular carcinoma (HCC) despite reduced expression of arginine synthesis genes, in murine and patient tumors. Tumor cells accumulate high levels of arginine due to increased uptake and reduced arginine-to-polyamine conversion. Importantly, the high levels of arginine promote tumor formation via further metabolic reprogramming, including changes in glucose, amino acid, nucleotide, and fatty acid metabolism. Mechanistically, arginine binds RNA-binding motif protein 39 (RBM39) to control expression of metabolic genes. RBM39-mediated upregulation of asparagine synthesis leads to enhanced arginine uptake, creating a positive feedback loop to sustain high arginine levels and oncogenic metabolism. Thus, arginine is a second messenger-like molecule that reprograms metabolism to promote tumor growth.
HostingRepositoryMassIVE
AnnounceDate2023-08-21
AnnouncementXMLSubmission_2023-08-21_02:50:14.776.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdanilo ritz
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-20 23:12:22ID requested
12023-08-21 02:50:15announced
Publication List
no publication
Keyword List
submitter keyword: Hepatocellular carcinoma, metabolism, arginine, urea cycle, ARG1, AGMAT, ASNS, RBM39
Contact List
Alexander Schmidt
contact affiliationBiozentrum, Universtiy of Basel, 4056 Basel, Switzerland
contact emailalex.schmidt@unibas.ch
lab head
danilo ritz
contact affiliationUniversity of Basel
contact emaildanilo.ritz@unibas.ch
dataset submitter
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MassIVE dataset URI
Dataset FTP location
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