PXD040952 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies |
| Description | We have developed a novel mTOR pathway inhibitor via targeting SIN1. We used multiple proteomics analyses to determine mechanism of action of our novel Sin1 inhibitor and compare to other mTOR pathway inhibitors. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-26_08:36:31.083.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michael Caldwell |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-03-17 14:09:05 | ID requested | |
| ⏵ 1 | 2026-01-26 08:36:31 | announced | |
Publication List
Keyword List
| submitter keyword: cancer, drug development,mTOR pathway |
Contact List
| Leonidas Platanias |
|---|
| contact affiliation | irector of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and the Jesse, Sara, Andrew, Abigail, Benjamin and Elizabeth Lurie Professor of Oncology in the Departments of Medicine and Biochemistry and Molecular Genetics. |
| contact email | l-platanias@northwestern.edu |
| lab head | |
| Michael Caldwell |
|---|
| contact affiliation | Northwestern University |
| contact email | michael.caldwell@northwestern.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD040952 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040952
- Label: PRIDE project
- Name: Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies
