PXD040948-2

PXD040948 is an original dataset announced via ProteomeXchange.

Title	The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression
Description	Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and PrrF2 small regulatory RNAs (sRNAs), which post-transcriptionally repress expression of non-essential iron-containing proteins thus sparing this nutrient for more critical processes.The genes for the PrrF1 and PrrF2 sRNAs are arranged in tandem on the chromosome, allowing for the transcription of a longer heme-responsive sRNA, termed PrrH. While the functions of PrrF1 and PrrF2 have been studied extensively, the role of PrrH in P. aeruginosa physiology and virulence is not well understood. In this study, we performed transcriptomic and proteomic studies to identify the PrrH regulon.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:00:08.222.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mehari Weldemariam
SpeciesList	scientific name: Pseudomonas aeruginosa; NCBI TaxID: 287;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-17 10:22:26	ID requested
1	2023-08-11 13:26:38	announced
⏵ 2	2024-10-22 06:00:08	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Pseudomonas aeruginosa, heme-responsive, iron, PrrF1

Maureen A. Kane
contact affiliation	Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD USA
contact email	mkane@rx.umaryland.edu
lab head
Mehari Weldemariam
contact affiliation	University of Maryland Baltimore
contact email	mweldemariam@rx.umaryland.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD040948
     1. Label: PRIDE project
     2. Name: The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression