PXD040893-1

PXD040893 is an original dataset announced via ProteomeXchange.

Title	Unbiased mapping of the MCU interactome
Description	Mitochondria play a key role in Ca2+ homeostasis and thus the regulation of metabolism and cell death. The MCU is an ion channel that mediates the rapid and highly selective uptake of Ca2+ into the mitochondrial matrix. However, an in-depth characterization of the molecular links that couple MCU-dependent Ca2+ entry with mitochondrial function is lacking. We performed 50 pulldowns from MCU complex reporter cell lines and built a protein network of statistically significant interactors
HostingRepository	PRIDE
AnnounceDate	2024-09-30
AnnouncementXML	Submission_2024-09-30_04:56:51.156.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marta Murgia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-15 09:01:18	ID requested
⏵ 1	2024-09-30 04:56:51	announced
2	2024-10-22 07:00:05	announced	2024-10-22: Updated project metadata.

10.1038/S44318-024-00219-W;

submitter keyword: MCU, proteomics,mitochondria, calcium

Fabiana Perocchi
contact affiliation	Helmholtz Diabetes Center Institute for Diabetes and Obesity (IDO), Munich, Germany
contact email	fabiana.perocchi@helmholtz-muenchen.de
lab head
Marta Murgia
contact affiliation	MPI Biochemistry
contact email	mmurgia@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD040893

PRIDE project URI

• PRIDE
  1. PXD040893
     1. Label: PRIDE project
     2. Name: Unbiased mapping of the MCU interactome