PXD040842-2

PXD040842 is an original dataset announced via ProteomeXchange.

Title	Acute murine cytomegalovirus infection boosts cell-type specific response andlipid metabolism changes in infant mice liver
Description	Human cytomegalovirus (HCMV) infection in infants cause severe diseasessuch as neonata hepatitis, However, the single-cell dimensiona description otthe immune cel alteration during the first virus exposure process in infantsremains poorly understood. The hepatocytes play an essential role in metabolichomeostasis and detoxification, The Concomitant Effects of CMV infection oriver lipid metabolism in infants are still unclear. Here, using single-cell RNAsequencing, we found MCMV can infect most cell types of infant mice liverchanging the number of immune cells, MCMV infection increases proliferatincsubset of Nos2+CD8 effectorcells and amonocytes，which may plalimportant roles in the early anti-viral process. Furthermore, MCMV infectiorsubvert the protein expression profile of lipid metabolism in hepatocytesOverall, our data provide insights as to how the immune system response toMCMY infection during the early stage of infection, and the impact of infectionon lipid metabolism in infant mice hepatocvtes.
HostingRepository	iProX
AnnounceDate	2023-03-13
AnnouncementXML	Submission_2023-08-29_21:46:20.579.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anmin Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	TMT6plex reporter fragment
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-13 19:53:14	ID requested
1	2023-08-08 20:40:51	announced
⏵ 2	2023-08-29 21:46:21	announced	2023-08-30: Update publication information.

Gao J, Wang A, Bu X, Jia W, Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice. Front Immunol, 14():1169869(2023) [pubmed]

submitter keyword: mice, liver, MCMV

Weidong Jia
contact affiliation	University of Science and Technology of China
contact email	jwd1968@ustc.edu.cn
lab head
Anmin Wang
contact affiliation	University of Science and Technology of China
contact email	amwang13@163.com
dataset submitter

iProX dataset URI