PXD040807-1

PXD040807 is an original dataset announced via ProteomeXchange.

Title	Proteomic profile in the diagnostics of portal hypertension in patients with compensated advanced liver disease
Description	Study aim: To compare proteomic profiles of patients with compensated advanced liver disease with and without clinically significant portal hypertension (CSPH) and by analyzing differently expressed proteins to identify potential new serum biomarkers for the early diagnosis of CSPH. Subjects and methods: Patients with compensated advanced liver disease will be included in the study. Two groups will be separated based on the presence of CSPH assessed by hepatic vein pressure gradient. High performance liquid chromatography and mass spectrometry will be used to determine the protein composition of the pooled samples. Bioinformatic tools and literature review will be used to analyze the significance and biologic role of the identified proteins. Expected scientific yield: We expect by analyzing differently expressed proteins and biological processes to identify potential biomarkers of CPSH and to provide additional insight to the pathogenesis of CSPH.
HostingRepository	PRIDE
AnnounceDate	2024-02-01
AnnouncementXML	Submission_2024-02-01_02:54:39.567.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ruđer Novak
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-13 05:53:33	ID requested
⏵ 1	2024-02-01 02:54:39	announced

Dataset with its publication pending

submitter keyword: proteomics, biological markers,liver cirrhosis, portal hypertension

Lovorka Grgurevic
contact affiliation	Lovorka Grgurevic M.D.,Ph.D. Professor of Human Anatomy Director - Center for Proteomics Center for Translational & Clinical Research Medical School University of Zagreb
contact email	lovorka.grgurevic@mef.hr
lab head
Ruđer Novak
contact affiliation	School of Medicine, University of Zagreb
contact email	rudjer.novak@mef.hr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD040807

PRIDE project URI

• PRIDE
  1. PXD040807
     1. Label: PRIDE project
     2. Name: Proteomic profile in the diagnostics of portal hypertension in patients with compensated advanced liver disease