PXD040786-2

PXD040786 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling identifies ITIH3 as a biomarker for disease activity in myasthenia gravis
Description	Myasthenia gravis (MG) is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Antibodies (Abs) against the acetylcholine receptor (AChR) are detected in approximately 85% of patients. Here, we aimed to study the serum proteome of MG and to identify novel biomarkers reflecting disease activity.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:13:43.103.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Hentschel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-10 23:26:42	ID requested
1	2023-10-25 01:11:20	announced
⏵ 2	2023-11-14 09:13:46	announced	2023-11-14: Updated project metadata.

Nelke C, Schroeter CB, Stascheit F, Huntemann N, Pawlitzki M, Willison A, R, ä, uber S, Melzer N, Distler U, Tenzer S, St, ü, hler K, Roos A, Meisel A, Meuth SG, Ruck T, Eculizumab treatment alters the proteometabolome beyond the inhibition of complement. JCI Insight, 8(13):(2023) [pubmed]

submitter keyword: machine learning,AChR, proteomics, treatment response, complement, myasthenia gravis, biomarker, ITIH

Tobias Ruck
contact affiliation	University Hospital Düsseldorf, Clinic for Neurology, Düsseldorf, Germany
contact email	Tobias.Ruck@med.uni-duesseldorf.de
lab head
Andreas Hentschel
contact affiliation	Leibniz Institut für Analytische Wissenschaften
contact email	andreas.hentschel@isas.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD040786

PRIDE project URI

• PRIDE
  1. PXD040786
     1. Label: PRIDE project
     2. Name: Proteomic profiling identifies ITIH3 as a biomarker for disease activity in myasthenia gravis