PXD040750-1

PXD040750 is an original dataset announced via ProteomeXchange.

Title	Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets
Description	In this study, we performed integrated multi-omics analyses using genomic (n = 79), transcriptomic (n = 42), proteomic (n = 224), and phosphoproteomic (n = 49) data collected from 224 samples from 168 patients with malignant and benign breast diseases. Our data revealed the characteristics of the linear multi-step progression of BRDC and provided a resource to explore the temporal order of a series of biological events in the progression of BRDC. In addition, we identified potential therapeutic agents, aspirin and dydrogesterone, that target AKR1C1 and demonstrated their inhibitory effect on tumor cells. In summary, our study helps to understand the progression of BRDC and provides an opportunity to treat BRDC in different stages.
HostingRepository	iProX
AnnounceDate	2024-08-02
AnnouncementXML	Submission_2024-08-02_04:29:27.107.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ganfei Xu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-09 20:06:10	ID requested
⏵ 1	2024-08-02 04:29:27	announced

Dataset with its publication pending

submitter keyword: Breast ductal carcinoma, Progression, Proteogenomics, Sterol hormone receptor conversion, AKR1C1

Chen Ding
contact affiliation	Fudan University
contact email	chend@fudan.edu.cn
lab head
Ganfei Xu
contact affiliation	Fudan University
contact email	ganfeix@fudan.edu.cn
dataset submitter

iProX dataset URI