PXD040742-1

PXD040742 is an original dataset announced via ProteomeXchange.

Title	Proteogenomic analysis of chemo-refractory high grade serous ovarian cancer
Description	To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers) and utilizing two biospecimen types (formalin-fixed paraffin-embedded and frozen tumor biopsies). As the largest and most comprehensive study of refractory ovarian cancers to date, this effort identified a 64-protein signature that predicts a subset of HGSOCs refractory to initial platinum-based therapy with high specificity and is validated in two independent patient cohorts. We also detected significant association between lack of Ch17 loss-of-heterozygosity and refractory disease. Moreover, based on protein pathway expression, five novel clusters of HGSOC were identified and validated across two independent patient cohorts, as well as in patient-derived xenograft (PDX) models. These clusters may represent different mechanisms of refractoriness and implicate putative therapeutic targets.
HostingRepository	PanoramaPublic
AnnounceDate	2023-09-18
AnnouncementXML	Submission_2023-09-18_21:49:39.601.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Jacob Kennedy
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	QTRAP 6500

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-09 17:56:15	ID requested
⏵ 1	2023-09-18 21:49:40	announced

Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Sch, ü, rer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG, Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer. Cell, 186(16):3476-3498.e35(2023) [pubmed]

submitter keyword: Human, FFPE, HGSOC, MRM

Jeff Whiteaker
contact affiliation	Fred Hutchinson Cancer Center
contact email	jwhiteak@fhcrc.org
lab head
Jacob Kennedy
contact affiliation	Fred Hutchinson Cancer Center
contact email	jkennedy@fhcrc.org
dataset submitter

Panorama Public dataset URI