PXD040724 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mitochondria preconditioning delays aging and associated diseases in C. elegans impacting on key ferroptosis players |
Description | Excessive iron accumulation or deficiency have detrimental consequences across species, leading to a variety of pathologies in humans. In the nematode Caenorhabditis elegans severe iron as well as oxygen deprivation induce developmental arrest. Instead, hypoxia preconditioning protects against severe hypoxia-induced neuromuscular damage and sub-lethal levels of iron depletion extend lifespan in C. elegans. The positive health outcomes of applying hypoxia preconditioning are obvious but have low feasible application. Here, we thus assessed the potential beneficial effects of genetic and chemical interventions acting via mild iron instead of oxygen depletion. We show that limiting iron availability through frataxin silencing or the iron chelator bipyridine, similar to hypoxia preconditioning, protect against hypoxia-, age- and proteotoxicityinduced neuromuscular deficits. Mechanistically, our data suggest that the beneficial effects elicited by frataxin silencing are at least in part mediated by counteracting ferroptosis, a form of non-apoptotic cell death specifically mediated by iron-induced lipid peroxidation. These is achieved by impacting on different key players of the ferroptosis machinery and likely via novel, gpx-independent redox systems. We thus point to ferroptosis inhibition as a novel strategy to promote healthy aging. |
HostingRepository | PRIDE |
AnnounceDate | 2023-04-17 |
AnnouncementXML | Submission_2023-04-17_10:28:11.446.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD040724 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | BerndThiede |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-09 06:53:11 | ID requested | |
⏵ 1 | 2023-04-17 10:28:12 | announced | |
2 | 2023-11-14 08:45:09 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD040724; |
Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, Nyg, å, rd S, Nilsen H, Ventura N, impacting on key ferroptosis players. iScience, 26(4):106448(2023) [pubmed] |
Keyword List
submitter keyword: Aging |
C. elegans |
fatty acids |
ferroptosis |
frataxin |
hypoxia |
iron |
mitochondria |
neurodegeneration |
oxidoreductase |
Contact List
Hilde LogeNilsen |
contact affiliation | Institute of Clinical Medicine, Department of Clinical Molecular Biology, University of Oslo, Norway |
contact email | h.l.nilsen@medisin.uio.no |
lab head | |
BerndThiede |
contact affiliation | University of Oslo |
contact email | bernd.thiede@ibv.uio.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040724
- Label: PRIDE project
- Name: Mitochondria preconditioning delays aging and associated diseases in C. elegans impacting on key ferroptosis players