PXD040722-2

PXD040722 is an original dataset announced via ProteomeXchange.

Title	The mouse aging proteomic atlas
Description	This database provides TMT-labeled proteomic data of aorta (thoracic aorta), brain, heart, kidney, liver, lung, muscle (gastrocnemius muscle), and skin (abdominal skin) of 6, 15, 24, and 30 months old male C57BL/6 mice. In addition to the whole-tissue lysate, low-soluble protein-enriched fraction was also analyzed for heart, kidney, lung, muscle, and skin. Bulk RNA-Seq data are available for brain, heart, kidney, liver, lung, muscle, and skin. The tissues used for transcriptomic analysis and proteomic analysis of whole-tissue lysate and low-soluble protein-enriched fraction were collected from the same mice. All analyses were conducted with 4 biological replicates.
HostingRepository	PRIDE
AnnounceDate	2024-10-03
AnnouncementXML	Submission_2024-10-03_01:34:11.120.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frank Stein
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-09 06:24:59	ID requested
1	2024-09-17 03:24:25	announced
⏵ 2	2024-10-03 01:34:12	announced	2024-10-03: Updated project metadata.

Takasugi M, Nonaka Y, Takemura K, Yoshida Y, Stein F, Schwarz JJ, Adachi J, Satoh J, Ito S, Tombline G, Biashad SA, Seluanov A, Gorbunova V, Ohtani N, An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation. Nat Commun, 15(1):8520(2024) [pubmed]

10.1038/s41467-024-52845-x;

submitter keyword: Proteome,Aging, Multi-omics

Naoko Ohtani
contact affiliation	Osaka Metropolitan University Graduate School of Medicine
contact email	naoko.ohtani@omu.ac.jp
lab head
Frank Stein
contact affiliation	EMBL
contact email	frank.stein@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD040722

PRIDE project URI

• PRIDE
  1. PXD040722
     1. Label: PRIDE project
     2. Name: The mouse aging proteomic atlas