PXD040663 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA |
Description | Pyrvinium pamoate, an anthelmintic drug, inhibits mitochondrial biogenesis during initial T-cell activation; however, its molecular target(s) and mechanism of action are unknown. In this study, we treated Jurkat T cell lysate with pyrvinium pamoate (5 nM and 50μM) and used proteome integral solubility alteration (PISA), to identify potential targets. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:49:31.175.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Brandon Gassaway |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-07 10:17:06 | ID requested | |
1 | 2023-08-28 19:46:58 | announced | |
⏵ 2 | 2023-11-14 07:49:31 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mitochondria, Pyrvinium Pamoate, Jurkat T cells, PISA |
Contact List
Steven Gygi |
contact affiliation | Harvard Medical School, Department of Cell Biology |
contact email | steven_gygi@hms.harvard.edu |
lab head | |
Brandon Gassaway |
contact affiliation | Harvard Medical School |
contact email | brandon_gassaway@hms.harvard.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD040663 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040663
- Label: PRIDE project
- Name: Identifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA