PXD040625 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HISTOLOGICAL AND PROTEOMIC CHARACTERIZATION OF MUSCULOSKELETAL AMYLOIDOMAS |
| Description | We report the histological and immunohistochemical features of four cases of musculoskeletal amyloidoma in association with combined laser capture microdissection (LCM) of Congo Red (CR)-positive regions with a recent microproteomics workflow that improves the sensitivity of the analysis in order to confirm the nature of the protein deposit. Proteomics techniques allowed to elucidate the nature of the amyloid protein deposit, improving the results obtained by immunohistochemistry (IHC). IHC results were confirmed in two cases while laser-capture microdissection coupled with bottom-up microproteomics was necessary to type the other two cases, for which IHC was inconclusive. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-05 |
| AnnouncementXML | Submission_2026-03-05_00:42:53.838.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Francesco Greco |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-03-06 08:29:20 | ID requested | |
| ⏵ 1 | 2026-03-05 00:42:54 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics,amyloidoma, LC-MS/MS |
Contact List
| Liam A. McDonnell |
|---|
| contact affiliation | Fondazione Pisana per la Scienza ONLUS |
| contact email | l.a.mcdonnell@outlook.com |
| lab head | |
| Francesco Greco |
|---|
| contact affiliation | Fondazione Toscana Gabriele Monasterio |
| contact email | f.greco@fpscience.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD040625 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040625
- Label: PRIDE project
- Name: HISTOLOGICAL AND PROTEOMIC CHARACTERIZATION OF MUSCULOSKELETAL AMYLOIDOMAS
