PXD040582 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome characterization of HCMV virus microenvironment with addition of cidofovir |
Description | The control of host processes which influence cell-cell communication is central to determining the outcome of a virus infection in tissue. Despite this, it remains unclear how cells either in close or distant proximity to an infected cell differentially respond to the primary infection. Here, we established a virus infection microenvironment to resolve molecular features and functional consequences of cell spatial address within this localized niche by mass spectrometry. To rule out the possibility that neighboring cells are infected by the viral progeny from the primary infection, cidofovir is added in the system to prevent viral genome replication in order to prevent the spread of infection. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:48:04.688.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bokai Song |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-03 08:48:11 | ID requested | |
1 | 2023-05-11 11:54:41 | announced | |
⏵ 2 | 2023-11-14 08:48:05 | announced | 2023-11-14: Updated project metadata. |
Publication List
Song B, Sheng X, Justice JL, Lum KK, Metzger PJ, Cook KC, Kostas JC, Cristea IM, Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections. Sci Adv, 9(19):eadg3433(2023) [pubmed] |
Keyword List
submitter keyword: HCMV, innate immunity, membrane contact sites, mass spectrometry,virus microenvironment, cell cycle, cidofovir |
Contact List
Ileana Cristea |
contact affiliation | Department of Molecular Biology, Princeton University |
contact email | icristea@princeton.edu |
lab head | |
Bokai Song |
contact affiliation | Princeton University |
contact email | bokais@princeton.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD040582 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040582
- Label: PRIDE project
- Name: Proteome characterization of HCMV virus microenvironment with addition of cidofovir