PXD040530-1

PXD040530 is an original dataset announced via ProteomeXchange.

Title	Bleomycin model of fibrosis and resolution phase in old and young mice
Description	Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of aging. Young (3 months) and old (21 months) mice were treated with Bleomycin or with control saline solution and analyzed transcript and protein expression over 8 weeks (Day 0, 14, 21, 28, 35, 42, 49, 56).
HostingRepository	PRIDE
AnnounceDate	2024-09-10
AnnouncementXML	Submission_2024-09-10_11:33:49.614.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Veyel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-01 09:22:13	ID requested
⏵ 1	2024-09-10 11:33:50	announced
2	2024-10-22 06:57:57	announced	2024-10-22: Updated project metadata.

Weckerle J, Mayr CH, Fundel-Clemens K, L, ä, mmle B, Boryn L, Thomas MJ, Bretschneider T, Luippold AH, Huber HJ, Viollet C, Rist W, Veyel D, Ramirez F, Klee S, K, ä, stle M, Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice. Am J Respir Cell Mol Biol, 69(4):422-440(2023) [pubmed]

10.1165/rcmb.2023-0012oc;

submitter keyword: Bleomycin, DIA,Mouse, lung, fibrosis, age

Wolfgang Rist
contact affiliation	Boehringer Ingelheim Pharma GmbH & Co. KG Drug Discovery Sciences
contact email	wolfgang.rist@boehringer-ingelheim.com
lab head
Daniel Veyel
contact affiliation	Boehringer Ingelheim Pharma GmbH & Co. KG
contact email	daniel.veyel@boehringer-ingelheim.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD040530

PRIDE project URI

• PRIDE
  1. PXD040530
     1. Label: PRIDE project
     2. Name: Bleomycin model of fibrosis and resolution phase in old and young mice