PXD040429-1

PXD040429 is an original dataset announced via ProteomeXchange.

Title	New Pathophysiological Insights from Serum Proteome Profiling in Equine Atypical Myopathy.
Description	Equine atypical myopathy (AM) is a severe environmental intoxication linked to the ingestion of protoxins contained in seeds and seedlings of the sycamore maple (Acer pseudoplatanus) in Europe. The toxic metabolites cause a frequently fatal rhabdomyolysis syndrome in grazing horses. Since toxic metabolites can also be present in co-grazing horses, it is still unclear as to why, in a similar environmental context, some horses show signs of AM whereas others remain clinically healthy. Label-free proteomics analyses on the serum of 26 diseased AM, 23 co-grazers and 11 control horses were performed to provide insights into biological processes and pathways. A total of 43 and 44 differentially expressed proteins between “AM vs co-grazing horses” and “AM vs control horses” were found. Disease-linked changes in the proteome of different groups were found to correlate with detected amounts of toxins and principal component analysis was performed to identify the 29 proteins with the greatest impact on the proteomic differences between groups. Among the pathway-specific changes the glycolysis/gluconeogenesis pathway, the coagulation/complement cascade, and the biosynthesis of amino acid were affected. Sycamore maple poisoning results in a combination of inflammation, oxidative stress, and high energy demand, which is trying to be met by enhanced glycolysis.
HostingRepository	PRIDE
AnnounceDate	2024-02-09
AnnouncementXML	Submission_2024-02-09_04:13:23.413.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marc Dieu
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-27 05:19:53	ID requested
⏵ 1	2024-02-09 04:13:23	announced

10.1021/ACSOMEGA.3C06647;

submitter keyword: equine atypical myopathy

Acer spp.

label-free proteomics

serum proteomics

blood biomarkers.

Dominique-M. Votion
contact affiliation	Department of Functional Sciences, Faculty of Veterinary Medicine, Pharmacology and Toxicology, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000 Liège 1 (Sart Tilman), Belgium
contact email	dominique.votion@uliege.be
lab head
Marc Dieu
contact affiliation	University of Namur - MaSUN
contact email	marc.dieu@unamur.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD040429

PRIDE project URI

• PRIDE
  1. PXD040429
     1. Label: PRIDE project
     2. Name: New Pathophysiological Insights from Serum Proteome Profiling in Equine Atypical Myopathy.