PXD040301-2

PXD040301 is an original dataset announced via ProteomeXchange.

Title	PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
Description	Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To map the ubiquitination site of RIPK1 regulated by PPDPF, we performed MS analysis using control and RIPK1-overexpressing HEK293T cells with or without PPDPF overexpression
HostingRepository	iProX
AnnounceDate	2023-02-21
AnnouncementXML	Submission_2024-06-06_01:11:59.959.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yikang Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-20 22:50:31	ID requested
1	2023-02-20 22:51:07	announced
⏵ 2	2024-06-06 01:12:00	announced	2024-06-06: Update information.

Wang YK, Ma N, Xu S, Huang JY, Ni QZ, Cao HJ, Zheng QW, Zhu B, Xia J, Zhang FK, Ding XF, Qiu XS, Chen TW, Wang K, Chen W, Li ZG, Cheng SQ, Xie D, Li JJ, PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1. Cell Rep, 42(4):112340(2023) [pubmed]

submitter keyword: Ubiquitination, RIPK1, LCMS, 293T

Jingjing Li
contact affiliation	Shanghai Institute of Nutrition and Health
contact email	tide7@163.com
lab head
Yikang Wang
contact affiliation	Shanghai Institute of Nutrition and Health
contact email	wangyikang2017@sibs.ac.cn
dataset submitter

iProX dataset URI