PXD040221-1

PXD040221 is an original dataset announced via ProteomeXchange.

Title	Enamel proteins reveal biological sex and intrataxon variability within Paranthropus robustus
Description	The evolutionary relationships among extinct African hominin species are highly debated and largely unresolved, due in part to a lack of molecular data. Even within taxa, it is not always clear, based on morphology alone, whether ranges of variation are due to sexual dimorphism versus potentially undescribed taxonomic diversity. For Paranthropus robustus, a Pleistocene hominin found only in South Africa, both phylogenetic relationships to other taxa, and the nature of intraspecific variation are still debated. Here we report the first successful mass spectrometric sequencing of enamel proteomes from four ca. 2 million years old dental specimens morphologically identified as P. robustus from the site of Swartkrans.
HostingRepository	PRIDE
AnnounceDate	2025-06-09
AnnouncementXML	Submission_2025-06-09_08:05:29.115.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Claire Koenig
SpeciesList	scientific name: Homo; NCBI TaxID: 9605;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Exploris 480; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-17 01:20:00	ID requested
⏵ 1	2025-06-09 08:05:29	announced

Madupe PP, Koenig C, Patramanis I, R, ü, ther PL, Hlazo N, Mackie M, Tawane M, Krueger J, Taurozzi AJ, Troch, é G, Kibii J, Pickering R, Dickinson MR, Sahle Y, Kgotleng D, Musiba C, Manthi F, Bell L, DuPlessis M, Gilbert C, Zipfel B, Kuderna LFK, Lizano E, Welker F, Kyriakidou P, Cox J, Mollereau C, Tokarski C, Blackburn J, Ramos-Madrigal J, Marques-Bonet T, Penkman K, Zanolli C, Schroeder L, Racimo F, Olsen JV, Ackermann RR, Cappellini E, . Science, 388(6750):969-973(2025) [pubmed]

10.1126/science.adt9539;

submitter keyword: human evolution, sequence reconstruction, dental enamel,Palaeoproteomics, Enamel

Jesper V. Olsen
contact affiliation	Professor, NNF-Center for Protein Research, University of Copenhagen, Denmark
contact email	jesper.olsen@cpr.ku.dk
lab head
Claire Koenig
contact affiliation	Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
contact email	claire.koenig@cpr.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD040221

PRIDE project URI

• PRIDE
  1. PXD040221
     1. Label: PRIDE project
     2. Name: Enamel proteins reveal biological sex and intrataxon variability within Paranthropus robustus