PXD040155-1

PXD040155 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
Description	Thermal Proteome Profiling (TPP) allows for identification of drug (off-)targets by evaluating shifts in apparent melting temperature for proteins. In this study, we use TPP to identify the targets for a novel antifolate (C1).
HostingRepository	PRIDE
AnnounceDate	2023-08-08
AnnouncementXML	Submission_2023-08-08_02:40:47.990.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	DickZijlmans
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 08:00:12	ID requested
⏵ 1	2023-08-08 02:40:48	announced
2	2024-10-22 05:59:56	announced	2024-10-22: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Antifolates, targetable vulnerability, DHFR, FPGS, one-carbon metabolism

submitter keyword: Antifolates, targetable vulnerability, DHFR, FPGS, one-carbon metabolism

Contact List

MichielVermeulen
contact affiliation	Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands
contact email	michiel.vermeulen@ru.nl
lab head
DickZijlmans
contact affiliation	Radboud Universiteit Nijmegen
contact email	d.zijlmans@science.ru.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD040155
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD040155

PRIDE project URI

Repository Record List

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